Clinical research has fundamentally discriminated women, assuming that they are nothing more than “small” men and therefore, drugs should work mostly the same if just adjusting the dose to their lower weight.

However, this has been proven not to be the case. The physiology of the two sexes differs in several parameters, that is why women suffer 50–75% more adverse reactions from drugs than men. New research in mice offers new evidence of why not performing clinical research in females is dangerous, not only to drug research but to women.

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