How an organism can sense and cope with warming temperatures is key for survival, particularly under current global warming trends. The importance of this subject was recognised by 2021’s Nobel prize in Physiology & Medicine awarded to work on TRP channels, key mammalian peripheral heat sensors.
Endotherms -such as mammals and birds- maintain their body temperature through skin-based TRP channels that relay temperature information to a region of the brain called the hypothalamus, where specific neurons act as a thermostat to regulate body temperature.
C. elegans as a model for ectotherm temperature regulation
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