Fathers (Also) Shape Embryonic Development

Can a father’s lifestyle choices before conception influence the health of his future children? New research reveals that environmental factors affecting fathers can leave molecular footprints in embryos, shaping development and potentially impacting long-term health.
For decades, scientists believed that inheritance was controlled exclusively by DNA sequences passed from parents to offspring. Today, researchers recognize the critical importance of epigenetic inheritance—the transmission of biological traits through chemical modifications to DNA and its associated proteins.
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please note that there is an error in the link to the original publication in the article on MappingIgnorance. In the text, there is a link to a comprehensive review on the topic whereas at the end, the citation should refer to the original research article
Dura, M., Ranjan, B., Serrano, J.B. et al.Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds. EMBO J44, 6750–6781 (2025). https://doi.org/10.1038/s44318-025-00556-4