It seems that the genetic risk of an APOE4 variant in the APOE gene, not only increases risk for Alzheimer’s but also increases the chances of getting infected by the COVID-19 virus. The APO protein is involved in cholesterol metabolism and the immune system. However, its precise role in Alzheimer’s disease is as of yet…

Humans are not the only animals with a taste for alcohol. It has been described in different animals in the wild, especially mammals, that they do like to eat overripe fermented fruit, and with it experience similar effects to the ones we are all familiar with. It turns out that some mammals cannot take their…

Stem cells were the pioneering force behind the new wave of personalized medicine of the last decade, while CRISPR and other gene-editing techniques have come to revolutionize gene therapy and the treatment of genetic diseases. It had to happen that they would eventually join forces. A new study has used gene-edited stem cells to revert…

Gene therapy was a 90s hit. The most promising medical advance of the decade was almost forgotten after some really serious side effects occurred in one clinical trial, but after nearly 3 decades a small trial in Germany has shown gene therapy not only to be safe for use in humans but also to have…

Believe it to not, little worms (C.elegans) are an useful tool for researchers studying aging. Specially, the genetics of aging. A recently released article in Cell Reports shows that gene modification in two specific cellular pathways drives 500% life extension in worms. Why worms? IF you want to kow the answer to this question, go…

We all know exercise is important to be healthy, every doctor in the world would tell you so. Now, new research in the journal Nature Communications, we also know who to thank for. Sestrins, a protein family has been linked to the health benefits of exercise. Sestrins improve physical performance To learn how they do…

I am sure you know people who have decided to go gluten free because they want to be healthy. However, for most of these people buying gluten free products is just a way of throwing money away since only about 1-2% of Europeans suffer gluten intolerance (celiac disease). Could it be that a bacteria is…

That female fertility is not stable during a woman’s lifetime is nothing new, but now a new study in the journal Science has found an explanation to its inverted U shape: chromosome errors! So it turns out female fertility might be limited by chromosome errors. Let’s look at the findings from the study in MappingIgnorance.org

After the big scandal of the CRISPR babies at the end of 2018, some might have thought that would be the end of CRISPR in the clinic, but luckily that has not been the case and despite the public outrage of last year, today we can report on its successful use as gene therapy against…

One of the most studied, most promising avenues for improving what is known as “healthy” aging is fasting. Yes, terrible as it might seem to food lovers all around the world it seems, at least in animal models, that fasting is a good way forward. So much so that 24-hour fasting seems to help rejuvenate…